|
Analgesic Overuse Headache
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
When genotype distribution for RAMP1 rs7590387 was compared between healthy controls (n = 209) and MOH patients, carriers of rs7590387GG were found at lower risk of developing MOH (OR: 0.43, 95%CI: 0.22-0.85, P = 0.011).
|
25881990 |
2015 |
|
Hypertensive disease
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We hypothesized that upregulation of RAMP1 would favorably enhance autonomic regulation and attenuate hypertension.
|
20100989 |
2010 |
|
Common Migraine
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We herein investigated the role of polymorphisms in calcitonin gene-related peptide (CGRP)-related genes looking at the association of rs3781719 (T > C) in the calcitonin gene-related polypeptide-alpha (CALCA) gene and of rs3754701 (T > A) and rs7590387 (C > G) at the receptor activity modifying 1 (RAMP1) locus with triptan response in patients with migraine without aura (MwoA).
|
25881990 |
2015 |
|
Fibrous Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have identified several genes (BMPR1B, DMD, RAMP1) with expression signatures specific for fibrous meningiomas.
|
18365142 |
2008 |
|
Septicemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of CRLR and RAMP1, 2, and 3 in several tissues from mice in a sepsis model induced by lipopolysaccharide (LPS).
|
10777702 |
2000 |
|
Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of CRLR and RAMP1, 2, and 3 in several tissues from mice in a sepsis model induced by lipopolysaccharide (LPS).
|
10777702 |
2000 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a RAMP1 knockout-mouse (RAMP1<sup>-/-</sup>) we examined the role of the CGRP-receptor in the acute-phase of cerulein-induced pancreatitis.
|
31109903 |
2019 |
|
Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction.
|
18198792 |
2007 |
|
Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction.
|
18198792 |
2007 |
|
Cerebrovascular accident
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction.
|
18198792 |
2007 |
|
Asthma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To determine whether functional RAMP1 is expressed by airway epithelial cells and whether there are alterations in asthma.
|
20933260 |
2010 |
|
Migraine Disorders
|
0.060 |
PosttranslationalModification
|
group |
BEFREE |
This study provides the first evidence that DNA methylation at RAMP1 promoter might play a role in migraine.
|
26501962 |
2015 |
|
Essential Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that this T-A-T RAMP1 gene haplotype might have utility as a genetic marker for EH and that the RAMP1 gene or a neighbouring gene may be associated with increased susceptibility to EH.
|
28181496 |
2017 |
|
Migraine Disorders
|
0.060 |
Biomarker
|
group |
BEFREE |
These results demonstrate that RAMP1 is functionally rate limiting for CGRP receptor activity in the trigeminal ganglion, which raises the possibility that elevated RAMP1 might sensitize some individuals to CGRP actions in migraine.
|
17344407 |
2007 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data provide novel insights into the role of RAMP1 in promoting prostate tumorigenesis and support the potential of RAMP1 as a novel biomarker and possible therapeutic target in prostate cancer.
|
23867798 |
2013 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The study compared the severity of colitis in wild-type (WT) mice, mice treated with a CGRP receptor antagonist (CGRP<sub>8-37</sub> ), and RAMP1 knockout (<sup>-/-</sup> ) mice.
|
27513455 |
2017 |
|
Cerebral Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the T-A-C haplotype is a genetic marker for CI, and that RAMP1 or neighbouring genes are associated with increased susceptibility to CI.
|
19710695 |
2010 |
|
early pregnancy
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The present study was designed to determine the cellular localization of CALCA and its receptor components, CALCRL and receptor activity modifying protein 1 (RAMP1), at the human implantation site during early pregnancy; to assess whether CALCA regulates in vitro angiogenesis of human endothelial cells; and to examine whether CALCA can improve angiogenic imbalance in preeclamptic placental explants.
|
17267696 |
2007 |
|
Chronic acquired lymphedema
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study examined whether RAMP1 plays a role in increased lymphangiogenesis during secondary lymphedema.
|
29078910 |
2017 |
|
Migraine Disorders
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds.
|
31756985 |
2019 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The findings for this study are: 1) relaxation responses of OA were higher for bradykinin (78.55 ± 3.91 vs 52.67 ± 2.19; P < .05) in pregnancy with FGR compared to the normal, 2) relaxation response of OA segments to CGRP was similar with no change in the expression of G-protein couple receptor-calcitonin receptor-like receptor complex in normal healthy pregnancy and pregnancy complicated by FGR, 3) maximal relaxation response of OA were significantly (P < .05) lower for both ADM (18.2 ± 6.7 vs 38 ± 2.5) and ADM2 (26.9 ± 6.7 vs 48 ± 2.6) along with decreases in their respective ligand-receptor complex in FGR compared to the normal pregnancies, 4) expression of calcitonin receptor-like receptor mRNA was higher but its immunoreactivity was lower in OA from FGR pregnancy compared to the normal, and 5) mRNA and protein levels of RAMP1, RAMP2, and RAMP3 were lower in OA isolated from FGR pregnancies compared to the normal.
|
27258937 |
2016 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line.
|
24454825 |
2014 |